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In some cases, more than two HDACs play opposite roles in regulating the inflammatory response, suggesting that pan-HDAC inhibitors may result in unwanted effects

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Accessed 1 Feb 2020 Maiti A, Saha N, Shukla A, Sarkar S, Sil AK (2021) Cigarette smoke affects ESCRT-mediated vacuolar activity in Saccharomyces cerevisiae
Dry mouth (a side effect of smoking) worsens the issue by reducing saliva, which normally helps cleanse bacteria and food debris