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with the gene usually designated NFE2L2 ), as are enzymes involved in the regeneration of NADPH (glucose 6-phosphate 1-dehydrogenase (G6PD), 6-phosphogluconate (PGD), isocitrate dehydrogenase 1 (IDH1) and malic enzyme 1 (ME1)) and those involved in the synthesis of GSH (glutamate–cysteine ligase catalytic (GCLC) and glutamate–cysteine ligase modifier (GCLM) subunits) [36–41] suggests that the Nrf2 transcription factor makes a substantial contribution to the efficiency of reduction of H 2 O 2 by PRDX

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J Natl Cancer Inst 113(2):208-211, 2021