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It is now widely accepted that the age-associated reduction in circulating hormones, particularly estrogen, directly accelerates skin aging, a major clinical consequence being delayed repair leading to an increased incidence of chronic wounds

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Figure 9 MSH functions as a cofactor for many redox enzymes that are involved in the detoxification of peroxides, electrophiles (formaldehyde), NO, aromatic compounds (maleylpyruvate) and arsenate (Fahey, 2013) (Table 1)