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in Nature Medicine demonstrated that blocking NNMT in white adipose tissue increased energy expenditure, reduced fat mass, and improved insulin sensitivity in animal models — even without changes in diet or activity (Kraus et al., Nature Medicine )

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Where a compound reaches the CNS at all by this route, it does so across the nasal mucosa and then along nerve rather than through blood, and CNS delivery of that kind has been demonstrated for a handful of molecules and assumed for many more

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