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Fertility, pregnancy, and fetal development-specific data are extremely limited, so reproductive use is extrapolated from other human data and animal studies

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Whether the impact of anesthesia followed by pain management has the same effects on the antioxidant system as abuse of opioids, amphetamines and other drugs affecting these systems is an issue that needs further research since such effects may be assumed to be a function of drug dosage, means of delivery, length of use and the degree to which tolerance develops