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Expression of p63 and Axin2 then decreased at 5 to 7 d post-infection, regardless of whether the cells were incubated in 50% or 5% CM at day 3 post-infection, showing that either extended culture or lower CM percentage can reduce Wnt signalling

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Researchers comment that a single introduction of the peptide may upregulate growth hormone production by somatotrophs for prolonged periods of time, thus apparently contributing “ to an overall increase in [growth hormone] secretion … by 46% ” and also potentially upregulating its main anabolic mediator insulin-like growth factor-1 (IGF-1) by 45% on average