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These results indicated that TG2 interferes with the protein–protein interactions of GST-fused proteins by crosslinking the GST tag

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GPX, the most prominent family of enzymes within the glutathione metabolic pathway, can catalyze the reduction of hydrogen peroxide and organic peroxides and convert these harmful oxidants into harmless water or alcohols, thereby mitigating oxidative damage to cells and maintaining the redox balance 40