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Simeon et al.)

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Overall, the core molecular machinery of ferroptosis is regulated by various cellular signalling pathways and genes but is primarily mediated through two main pathways, namely, extrinsic or transporter-dependent pathways (e.g., reduced cysteine or glutamine uptake and increased iron uptake) and intrinsic or enzyme-regulated pathways (e.g., inhibition of glutathione (GSH) peroxidase 4 (GPX4) antioxidant system) (Fig