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Nonetheless, these mice harbored activated mucosal immune components as demonstrated by increased numbers of lamina propria CD4(+)lymphocytes, redistribution of CD11c(+)cells, increased production of the proinflammatory cytokines interferon-γ and tumor necrosis factor-α (TNF-α), and expression of epithelial major histocompatibility complex class-I

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NAD+ depletion contributes to obesity and metabolic disorders