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Either it can be through redox reaction in reduction of peroxides by thiol peroxidases or most common reversible modification, S-glutathionylation by thiol transferases or in conjugation reactions of toxic metabolites through glyoxalase or a variety of other compounds by glutathione-S-transferases

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Some observational research has also suggested a slight increase in lung cancer risk linked to long-term, high-dose B6 and B12 supplementation, particularly among men and smokers, although this kind of study cannot prove that the supplements caused the cancers