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In general: If you follow a vegan, vegetarian, or low-meat diet and are not supplementing with vitamin B12 you might be at risk for deficiency

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[242] reported that cancer cells mediate EC activation, triggering the release of Weibel-Palade body contents (VWF, osteoprotegerin, angiopoietin-2), inducing angiogenesis and transendothelial migration, and promoting survival