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Mechanistic follow-up tied the raised SAM levels to elevated H3K4 histone methylation at promoters of favorable metabolic genes including PGC-1alpha (PPARGC1A), a master regulator of mitochondrial biogenesis and thermogenic programs, providing a plausible NNMT to SAM to histone-methylation to gene-expression chain

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Drinking water that is contaminated with trace amounts of metals (such as aluminum)