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In addition, with the development of AI (artificial intelligence) technology, the prediction accuracy of reactive metabolites is increasing year by year, and more accurate and comprehensive safety evaluations will be possible in the future

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Thus, activation of NFκB by ROS (or other signaling pathways) upregulates the expression and activity of ROS generators, such as NADPH oxidase 1 and 2 (NOX1 and NOX2) that produce superoxide [9, 10]

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