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Key properties: Stimulates GH release from the pituitary (not the hypothalamus) Does not significantly raise cortisol or prolactin Short half-life (~2 hours) — produces a sharp, pulsatile GH release Does not block somatostatin (the hormone that inhibits GH release) Selective for GH — minimal effect on other hormones The selectivity is what makes ipamorelin the preferred GHRP for most protocols