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On the other hand, this biomolecule is also able to alleviate angiogenesis, as both the reduced expression of vascular endothelial growth factor-A (VEGF-A) genes [50] as well as inhibition of the nuclear factor kappa B (NF-κB) pathway participating in neovascularization [48] were found in two studies on cellular models

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In severe or recurrent cases, a decrease in portal pressure is an ultimate goal of treatment which can be achieved by means of surgical portosystemic shunt or preferably transjugular intrahepatic portosystemic shunt (TIPS)[8]