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[DOI] [PMC free article] [PubMed] [Google Scholar] 165.Bonetto A., Penna F., Aversa Z., Mercantini P., Baccino F.M., Costelli P., Ziparo V., Lucia S., Rossi Fanelli F., Muscaritoli M

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The inhibition of Sirtuins 6 (SIRT6), a member of the Sirtuin family of NAD (+)-dependent enzymes, lead to the inactivation of the Keap1/Nrf2 signalling pathway and downregulation of GPX4, which overcomes sorafenib resistance by promoting ferroptosis in gastric cancer (Cai et al., 2021)