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But it's still an extrapolation, and reasonable extrapolation is not the same thing as evidence

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they enhance the rates of neutrophil infiltration in the intestinal mucosa and the gills, interfere with lipid, carbohydrate, amino acid, and nucleic acid metabolism, affect the antioxidant defense mechanism, reduce the post-hatching survival, and inhibit regulatory genes involved in development and functioning of the nervous system (Lu et al., 2016