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Additional risks associated with elevated homocysteine include: 3 Pregnancy complications (neural tube defects, preeclampsia, placental abruption) Down syndrome Osteoporosis Migraines PCOS The Bottom Line While elevated homocysteine is a concern, lowering the level can be accomplished through supplementing methylation cofactors including folate as 5-MTHF in order to bypass the MTHFR enzyme, as well as B12 as methylcobalamin, B6 as the active P5P form and B2

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Most people require dietary supplementation with VD to achieve the recommended blood levels of 25(OH)VD