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Prior studies have documented increased oxidative stress in CLN3 lymphoblasts and fibroblasts, and work in fruit flies has shown that CLN3 loss increases vulnerability to oxidative damage while CLN3 overexpression confers resistance, lending independent support to the connection the Norwegian team has now drawn in human astrocytes

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17 Sublingual B12 bypasses intestinal absorption issues, which makes it a more accessible treatment option for vitamin B12 deficiency