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Considering the significant diversity among patients with these complex disease conditions, the development of clinical trials focused on targeted treatments may prove to be the most impactful strategy overall

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Abbreviations BPTES 2-(5-phenyl-acetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide GLS glutaminase LC-MS/MS liquid chromatography tandem mass spectrometry Footnotes Authors’ Contributions DRS contributed to the study design and carried out all cell culture experiments, metabolite extraction and mass spectrometry analyses