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ROS or UV exposure disrupts Keap1’s conformation, releasing Nrf2 to translocate into the nucleus, where it activates antioxidant enzyme genes to establish cellular defense systems ( Curcumin targets the Keap1-Nrf2 pathway by modifying Keap1’s thiol groups, destabilizing the Keap1-Nrf2 complex, and blocking Nrf2 ubiquitination

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Effect of vitamin E supplementation on carbogen-induced amelioration of noise induced hearing loss in man