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Within the GLP-1 receptor agonist class , other options available in the UK include: Dulaglutide (Trulicity) – weekly injection with proven cardiovascular benefits [12] [17] Liraglutide (Victoza) – daily injection with proven cardiovascular benefits [13] Exenatide (Byetta) – twice-daily injection Exenatide extended-release (Bydureon) – weekly injection Lixisenatide (Lyxumia) – daily injection Tirzepatide (Mounjaro) – weekly injection that acts on both GLP-1 and GIP receptors [14] [15] Whilst these medications share similar mechanisms to semaglutide, individual tolerability varies