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When to increase dose Consider increasing if: Minimal response after 4-6 weeks at current dose No side effects at current dose Current dose below the higher end of recommended range Goals not being met with conservative approach Increase gradually, typically by 25-50% at a time

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TNFα increases phosphorylation of PLIN1 and decreases expression of both PLIN1 and G0S2 (180-182) thereby promoting greater basal lipolysis and release of FAs into plasma