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GPXs protect cells from oxidative damage by maintaining H 2 O 2 homeostasis and are primarily involved in the response and regulation of abiotic stress, such as metal, cold, drought, NaCl, and oxidative stress ( NnGPX in Nelumbo nucifera were significantly upregulated under conditions of low temperature, heat stress, mechanical damage, and salt treatment, and its overexpression markedly enhanced salt tolerance in rice ( GPX family were responsive to adverse stress conditions ( Figure 7 )