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In published preclinical work, KPV has been studied for inhibiting NF-κB activation in intestinal epithelial cells, with one widely cited study showing PepT1-mediated transport into colonic cells as part of its anti-inflammatory mechanism in mouse colitis models (Dalmasso et al., Gastroenterology , 2008)

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Patients who come in expecting appetite suppression similar to semaglutide will be disappointed if they do not understand what tesamorelin is actually doing