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The fact that these drugs based off our hormones are stable seems to be important to the longer-term effects were witnessing in pancreatic beta cells and other tissues, explained first author Sam Van de Velde, a staff scientist in Montminys lab

The patients who achieve lasting results are overwhelmingly those who view GLP-1 medications as part of a broader health transformation rather than a standalone solution

At 2.5 mg weekly, most people experience mild effects

That approach flagged variants of two genes - GLP1R and GIPR - both of which are directly targeted by the drugs that mimic the effects of our natural gut hormones