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Although the number of beige adipocytes did not increase, they displayed a more thermogenic phenotype characterized by smaller LDs, elevated expression of uncoupling protein 1 ( UCP1 ) and HSL , and enhanced glucose utilization, all features consistent with increased mitochondrial uncoupling and browning

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et al., Semaglutid and Cardiovascular Outcomes in Obesity without Diabetes, SELECT, N Engl J Med 2023

This process is essential for blood circulation and cardiovascular health

Gastrointestinal side effects, mostly with symptoms of transient fullness and nausea, are typical for the initiation of treatment