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As early as the mid-20th century, studies of commercial diet programs showed that while short-term weight loss was common, regaining weight long term was the norm
Weight loss of 15% or greater was achieved by 66.7% of participants at 9 mg and 75.0% at 10 mg, indicating robust responses across most participants rather than outlier-driven averages
Social media also strongly influenced how people viewed weight loss medications, often shaping expectations more than medical guidance
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Low-grade hot flashes, arthritis, arthralgia, and myalgia were more frequent in letrozole than placebo group in postmenopausal women with breast cancer after five years of letrozole therapy (81)
10.1371/journal.pbio.3000946 PLoS Biol
