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The reduced incretin effect of GIP in diabetic subjects may be due to the down-regulation of GIP receptor expression, which has been found in pancreatic islets of diabetic Zucker rats and reverted following correction of hyperglycemia [35]

the veins were already there

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It found that once-a-week semaglutide reduced drinking frequency and cravings over nine weeks compared to placebo

Hamilton GS et al

Efficacy and safety of exenatide once weekly versus liraglutide in subjects with type 2 diabetes (DURATION-6): a randomised, open-label study [abstract 75]
