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In the Step 1 trial (note: funded by Novo-Nordisk) of 1,961 individuals, the average weight loss at 68 weeks was 14.9% at the maximum dose of 2.4 mg weekly, equating to 15.3 kg (33.6 lbs) lost compared to 2.6 kg (5.7 lbs) in the placebo group

Best for self-pay users Treatments: injectable | Membership fee: none | Medication costs: $79+ to $299+/mo

The adoption curve is steepening

Changing the frequency of your injections, though, should only be done at the direction of your clinician

Thats true for anyone, but having bipolar disorder makes some of those risks more important to keep in mind

However, direct comparisons require caution because: Trial lengths differed Dosing protocols differed Patient populations differed Long-term orforglipron data is still developing A 5% to 10% reduction in body weight can still produce clinically meaningful improvements in blood pressure, insulin sensitivity, mobility, and metabolic health