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Although no data from head-to-head trials comparing retatrutide to other currently approved obesity treatments exist, data from the phase 2 studies with retatrutide suggest that at higher doses, retatrutide could lead to greater WL compared to the most efficacious approved treatments for obesity and T2D such as tirzepatide 15 mg and semaglutide 2.4 mg (Fig

Del Prato S, Kahn SE, Pavo I, Weerakkody GJ, Yang Z, Doupis J

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According to the National Institute of Diabetes and Digestive and Kidney Diseases, GLP-1 receptor agonists now produce 3 to 12% more weight loss than lifestyle intervention alone

J Invest Dermatol 141(12):2969-2972.e1