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81 Notably, there was no increased risk even among patients with pre-existing psychiatric illness, including depression or prior self-harm

In clinical trials, which compared people randomly assigned to the active drug or a placebo, participants receiving semaglutide or tirzepatide lost 15% to 20% of their body weight on average

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These practices may be due to medical providers having biases about which patients will be able to afford certain medications, or about the effectiveness of medications in different patient groups. Rocio Pereira, MD, chief of Endocrinology, Denver Health