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Understanding whether this represents a direct drug effect or a consequence of rapid metabolic changes is essential for appropriate management
In most cases, theres a trigger that makes it flare

EBioMed 2019;39:591602
doi: 10.1038/s41591-025-03774-9 182 GruberTLechnerFKriegerJPGarca-CceresC

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Under pancreatic cancer conditions, micro-RNAs (miRNAs) secreted from PDA activate PI3K/Akt/FoxO1 signal pathway to suppress myotube cells response to insulin in muscle tissue (Wang et al., 2017)
