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Weight loss can take place gradually over several months, while others experience weight reduction within weeks

Differences in receptor binding and pharmacodynamics could explain this observation, but further investigation is needed to determine whether the differences stem from drug properties, population characteristics or both. The authors also disclosed their inability to establish causality for the association between semaglutide and ocular AEs, noting that the biological mechanisms remain unclear

Still, questions remain about safety

The restoration of gut-metabolic-heart axis homeostasis and the recovery of structural and functional integrity in the cafeteria-diet-induced obesity model is achieved by semaglutide through these coordinated actions

Rapid improvements in blood sugar control can sometimes worsen diabetic retinopathy in the short term

In New York, the amendments also require coverage for over-the-counter methods and allow enrollees to obtain a 12-month supply of their contraceptive method at one time