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Effects on gastric emptying are significant and appear to lessen with long-term use, possibly due to tachyphylaxis of vagal nerve activation

Insurance coverage often depends on which brand name is prescribed, even though the medication is the same

Tirzepatide for diabetes: on track to SURPASS current therapy

PMID 21950636

Clinicians should therefore remain alert to emerging updates and apply flexible, evidence-based approaches

Biosimilar semaglutide development programs have been announced by 14 manufacturers globally, including Samsung Bioepis , Biocon Biologics , Sandoz , Mylan and Viatris , Hikma , and multiple Chinese biotechnology companies