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A 2022 meta-analysis confirmed the link, but the absolute number of extra cases per 1,000 people treated is small, so most users never develop a gallbladder problem

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And a prolonged low-calorie diet effectively generated an energy deficit, thereby sustaining weight loss

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The FDAs questions specifically relate to microbiology, assays, impurities and stability for both the lyophilized product and the final reconstituted drug product