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Portillo Canales and colleagues tracked 110 men with obesity - many also with type 2 diabetes - who were being treated with semaglutide, dulaglutide or tirzepatide, the active ingredients in Novo Nordisk's Wegovy and Ozempic or Eli Lilly's Trulicity, Mounjaro, and Zepbound

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Long-Term Use and What to Expect One important reality about GLP-1 medications is that they are often intended for long-term use

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Gastrointestinal side effects, if they occur, usually appear during this transition

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Conclusion: Effectively Managing Constipation on GLP-1 Medications Constipation from Ozempic, Wegovy, Mounjaro, and other GLP-1 receptor agonists is a common side effect, but it doesnt have to detract from the positive impacts these medications can have on diabetes management and weight loss

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That sudden urge for midnight snacks, sweets, or your favorite cookies often diminishes significantly

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subsequent weekly doses at the same level usually cause milder or no nausea

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