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inked a potential $938 million licensing deal for APL-18881 (HEC-88473), Sunshines dual fibroblast growth factor 21 (FGF21)/glucagon-like peptide-1 (GLP-1) receptor agonist currently in a phase II study for type 2 diabetes
In STEP-1 (semaglutide), lean mass decreased by ~9.7% while fat mass fell by ~19.3%, with the proportion of lean mass increasing by ~3 percentage points (35)
The initial weight loss in weeks 14 often includes both water weight and fat loss

Is it muscle or fat

These pleiotropic effects provide a rationale for exploring their role in multiple organ systems

Research shows that these hormones work together
