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Glucagon-like peptide-1 cleavage product GLP-1(9-36) reduces neuroinflammation from stroke via the activation of insulin-like growth factor 1 receptor in astrocytes

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The methods used in the scoping review and descriptive summaries of included systematic reviews can be found in Appendix A

How It Works Semaglutide is a GLP-1 receptor agonist that mimics a natural hormone in your body

In addition to its effects on metabolic regulation, GLP-1, when synthesized within the brain, exhibits neuroprotective properties.397,427,431 A clinical trial titled Liraglutide in Early Parkinsons Disease was published in the New England Journal of Medicine, exploring the effects of liraglutide on patients with early-stage PD diagnosed within the last three years.432 The research was a 14-month Phase II double-blind randomized controlled trial

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