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Naltrexone may enhance appetite suppression and increase energy expenditure when paired with semaglutide, though clinical evidence for this combination remains limited compared to GLP-1 monotherapy

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Additionally, it stimulates bacteria in the gut to use more glucose, thus decreasing blood sugar levels

Meta-analysis of effect of dipeptidyl peptidase-4 inhibitors on cardiovascularrisk in type 2 diabetes mellitus

95% CI, 0.99-1.21) and HCC (HR, 0.72

Both the LEADER (liraglutide) and SUSTAIN-6 (subcutaneous semaglutide) trials reported significant reductions in the primary outcome (incidence of MACE)