which glp-1 is the best for weight loss Loss: Oral vs Injectable Semaglutide, Side Effects, and Long-Term Tolerance Understanding Weight Loss Medications: GLP-1
Description
This means that it works by mimicking the action of both the GLP-1 and GIP hormones, which help regulate your metabolism
The Physiology of Glucagon-Like Peptide 1
This leads to: Increased Insulin Secretion: Helps control blood sugar levels, preventing spikes and crashes
The adaptive immune system
In December 2025, the TRIUMPH-4 trial reported that retatrutide 12 mg achieved a remarkable 28.7% mean weight loss at 68 weeks in patients with obesity and knee osteoarthritis, with substantial pain relief as well ( [71] )
The reason 'dose titration,' which involves starting with a small amount and gradually increasing it, is recommended is to minimize side effects
