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Dehydration can also worsen common tirzepatide side effects like constipation, which may indirectly affect appetite regulation

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This biased agonism means tirzepatide can enhance insulin secretion more effectively than semaglutide, particularly in people whose GLP-1 signaling is partially blunted

But tirzepatide consistently improves biomarkers that weight loss alone cannot fully explain

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FIGURE 8 Furthermore, the funnel plot exhibited a symmetrical distribution, indicating the absence of publication bias