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The effects on depression of internet-administered behavioural activation and physical exercise with treatment rationale and relapse prevention: study protocol for a randomised controlled trial

Understanding the lack of improved cardiovascular outcomes with GLP-1R agonists in ELIXA, EXSCEL, PIONEER 6, and FREEDOM CVOTs is complex, potentially originating from differences in trial design, variable sample sizes, discontinuation rates, follow-up durations, and challenges in achieving sustained pharmacokinetics during drug development

Adverse event-related discontinuation rates were 8% among liraglutide-treated patients compared to 4% of placebo recipients [44]

A monoclonal antibody called bimagrumab is currently in Phase 2 clinical trials at Eli Lilly
[DOI] [PubMed] [Google Scholar] 83.Villumsen M, et al

doi: 10.1136/jnnp.54.5.388, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 17.Guillot TS, Miller GW
