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GLP-1 Multiple studies in rodents have established the role of GLP-1 in bone metabolism

While lifestyle interventions such as diet and exercise can normalize HbA1c, the benefits of GLP-1RA and SGLT2-i extend well beyond glycemic control and justify continuation of therapy

Amino acid modifications in the N-terminus and at certain positions in the C-terminus are involved in the resistance to DPP-4 inhibition, thus prolonging its half-life

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In a phase 2b randomized clinical trial, bofanglutide demonstrated a strong efficacy in reducing blood sugar in people with type 2 diabetes

9-11 If a GLP-1 RA is determined to be the best option for the patient, pharmacists and providers should consider the following recommendations: Follow dosing recommendations as directed by the manufacturer