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In addition, Cushings syndrome and acromegaly are often medically treated with somatostatin analogues which can cause hyperglycaemic effects ( Treatment strategies for diabetes mellitus secondary to endocrine disorders According to the most recent international guidelines on type 2 DM (T2DM) management, the therapy should be patient-centred and not glycaemia-centred ( Metformin Metformin is generally the first approach for treatment of T2DM

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Furthermore, we found that treatment of human islets with a GLP-1R agonist increases active GLP-1 expression and increases PCSK1 expression in a subcluster of cells

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Ozempic (semaglutide) and Wegovy are popular drugs that mimic its effects