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4ac), revealing the essential role of CNS GIPR for the maximal weight loss response to combined GIPR blockade/GLP-1R activation

Author Bio Rebecca Kastin, NBC-HWC is a board-certified health and wellness coach and mind-body eating coach specializing in emotional eating, womens weight loss, hormone balance and sustainable behavior change

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The activation resulted in decreased levels of pro-inflammatory cytokines IL-1 and IL-6 in adipose tissue, ultimately reducing inflammation ( Metformin has been shown to have some anti-inflammatory effects in clinical studies in patients with T2DM, in experimental studies in rodent models of obesity and T2DM, and in vitro experiments with several immune cells ( in vitro , metformin reduces the inflammatory activation of macrophages by interfering with the metabolic changes linked to inflammation (Xiong et al., 2021)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Gharib SA, Manicone AM, Parks WC