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Results demonstrated mean weight reduction of 20.1% in participants without type 2 diabetes, with no plateau observed at the study endpoint

Research shows that most people regain approximately two-thirds of lost weight within one year of discontinuation

These findings suggest potential neuroprotective benefits of semaglutide, especially regarding cognitive health, and call for further research to validate its use in treating cognitive deficits and substance misuse in patients with T2DM (87)

Their therapeutic potential is evident in various disease contexts, including type 2 diabetes, neurodegenerative disorders, and inflammatory bowel disease (IBD)

All participants in this study had a body mass index (BMI) exceeding 35 kg/m 2 and had not previously used exenatide prior to study enrollment