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Taken together, additional studies are needed to fully clarify any cardioprotective effects of GLP-1 RA treatment directly on the heart

We were unable to block the GLP-1-elicited increase in heart rate using sympathetic blockers, an HCN channel blocker, cervical vagotomy, and ganglionic blockade

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Developed to investigate how the immune system responds to insulin, the Yalow and Berson method (figure 10) made it finally possible to accurately and rapidly measure tiny amounts of insulin and many other biologically interesting substances in a variety of body fluids, including blood, urine and saliva, as well as tissue extracts (Yalow, Berson)