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2020) While there have been improvements in cardiometabolic factors in response to GCGR activation such as body weight, steatohepatitis, and glucose homeostasis, there are concerns due to the potential impact of GCGR agonism on the heart

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Additionally, a recent meta-analysis of 13 trials investigating both GLP-1RAs and dual GIP/GLP-1 receptor agonists such as tirzepatide found similar reductions in major adverse cardiovascular events (MACE) and stroke, particularly ischaemic stroke (OR 0.74

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