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Native GLP-1 has no use therapeutically, but the advent of GLP-1R agonists that have much longer half-lives has enabled GLP-1based actions for therapeutic uses as a viable option 57 )

Both insulin resistance and hyperinsulinemia per se could be implicated in the case of lipedema, and both conditions could be either the consequence or the cause of a dysfunctional alteration in the adipose tissue [3,4,5,6]

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